Studies Mutation Rate of accumulation
(per month)
(95% CI)
Probabilities of accumulated mutations
0-3 month
window
3-6 month
window
6-9 month
window
9-12 month window At one
year
Sigaloff et al. [3] TAM2 0.07
(0.04-0.11)
0.1 0.27 0.4 0.52 0.32
NRTI-associated 0.03
(0.01-0.06)
0.04 0.13 0.2 0.27 0.16
Any NNRTI -associated 0.05
(0.03-0.09)
0.07 0.2 0.31 0.41 0.25
Cozzi-Lepri et al. [4] Any TAM mutation 0.02 0.03 0.09 0.14 0.19 0.11
Table 1: Probabilities of accumulated mutation for virological failure. 1We assumed virological failure distributed uniformly during one year, 25% of failures fail in the period 0-3 months after the previous viral load test, a further 25% in the period 3-6 months, 25% during 6-9 months and the final 25% during the period 9-12 months since the last viral load test. 2Thymidine Analogue Mutation (TAM). 3Yearly rate was given in the Cozzi_Lepri, et al. study and therefore confidence interval for monthly rate cannot be calculated.
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