CD4+ T-cell count Plasma HIV RNA
Time period Number of ART naive who received ARTa Mean before first ART, cells/µl Mean change after 6 month ART, cells/µl Mean before first ART, log Mean change after 6 month ART, log
Monotherapy era (1987-1995) 47 266 (192;339) 26 (-28;81) N/Ab N/Ab
Early cART era (1996-2004) 66 275 (223;326) 107 (71;143)* 4,35 (4,12;4,59) -2,19 (-2,51;1,87)*
Late cART era (2005-2012) 78 295 (223;367) 159 (129;189)*  4,67 (4,46;4,87) -3,20  (-3,46;-2,93)*
Total 191        
*Significant change (p<0.0001).
aHIV positive individuals who received ART for 6 months or more who have not received ART previously for more than 5 months. bPlasma HIV RNA measurements not done before 1996.
Table 3: The effect of ART on ART-naïve individual’s plasma HIV RNA and CD4+ T-cell count. 95% confidence interval in parentheses.
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