|
| Figure 2. P16INK4a immunostaining. A) Normal oral mucosa: weak nuclear immunostaining that decreases gradually from the basal layer to the surface (10x). B) Detail of normal oral mucosa from figure a, weak nuclear immunostaining in some cells and absent in others (40x). C) HPV-OL: generalized moderate intensity and increased protein expression compared to normal oral mucosa (10x). D) Detail of HPV-OL from figure c, moderate nuclear intensity immunostaining (40x). E) HPV-OL: generalized high intensity and increased protein expression (10x). F Detail of HPV-OL from figure e, high nuclear intensity immunostaining (40x). The arrow shows a koilocyte. |
