| |
Pre FDCAsa
N= 1,654 (%) |
Post FDCAsa
N=1,064 (%) |
pb |
TOTAL
N=2,718 (%) |
| Reverse transcriptasa |
| M184V/I |
823 (49.8) |
433 (40.7) |
<0.0001 |
1,256 (46.2) |
| T215Y/F |
675 (40.8) |
268 (25.2) |
<0.0001 |
943 (34.7) |
| M41L |
572 (34.6) |
212 (19.9) |
<0.0001 |
784 (28.8) |
| D67N |
421 (25.5) |
167 (15.7) |
<0.0001 |
588 (21.6) |
| L210W |
393 (23.8) |
146 (13.7) |
<0.0001 |
539 (19.8) |
| K70R |
291 (17.6) |
136 (12.8) |
0.001 |
427 (15.7) |
| K219Q/E |
274 (16.6) |
138 (13.0) |
0.01 |
412 (15.2) |
| L74V |
180 (10.9) |
67 (6.4) |
<0.0001 |
247 (9.2) |
| K65R |
119 (7.2) |
52 (4.9) |
0.01 |
171 (6.3) |
| TAMSc |
915 (55.3) |
367 (34.5) |
<0.0001 |
1,282 (47.2) |
| K103N |
512 (31.0) |
245 (23.0) |
<0.0001 |
773 (27.9) |
| V108I |
387 (23.4) |
183 (17.2) |
<0.0001 |
570 (21.0) |
| Y181C/I |
288 (17.4) |
106 (10.0) |
<0.0001 |
394 (14.5) |
| G190A/S |
155 (9.4) |
46 (4.3) |
<0.0001 |
201 (7.4) |
| Protease |
| L90M |
337 (20.4) |
126 (11.8) |
<0.0001 |
463 (17.0) |
| M46I/L |
302 (18.3) |
131 (12.3) |
<0.0001 |
433 (15.9) |
| V82A/F/T/S |
269 (16.3) |
98 (9.2) |
<0.0001 |
367 (13.5) |
| I84V |
123 (7.4) |
59 (5.5) |
0.05 |
182 (6.7) |
aFDCAs period: Pre FDCAs: patients with genotypical resistance test made from
January 2002 to June 2005; Post FDCAs patients with genotypical resistance test
made from July 2005 to June 2008.
bp value from chi-square test
cTAMS: Thymidine analog mutations: T215F/Y, M41L, D67N, L210W, K70R,
K219Q/E |
