OR (Post vs Pre FDCAs)c Confidence Interval 95% Any-class drug resistance 0.32   0.26 – 0.39 Two-class drug resistance 0.44 0.36 - 0.53 Multiple-class drug resistanced 0.34 0.25 – 0.45 TAMSe 0.44  0.36 – 0.54 M184I/Ve 0.58  0.49 – 0.68 L74I/Ve 0.58   0.42 – 0.80 K65Re 0.52 0.38–0.71 K103Nf 0.53 0.46–0.62 V108If 0.60 0.49–0.73 Y181C/If 0.50 0.40 – 0.63 G190A/Sf 0.34 0.25 – 0.48 L90Mg 0.45 0.36 – 0.58 M46I/Lg 0.67 0.51 – 0.86 V82A/F/T/Sg 0.44 0.33 – 0.58 I84Vg 0.49 0.34 – 0.71 aFDCAs period: Pre FDCAs: patients with genotypical resistance test made from January 2002 to June 2005; Post FDCAs patients with genotypical resistance test made from July 2005 to June 2008. bCo-variables included in the analysis: sex, age, country of origin, transmission group, prior AIDS, CD4, VL, number of treatment failures, time since HIV+ diagnosis, type of genotypic test, laboratory centre and class drug exposure (oneclass, two. or three-class). cOdds ratios in the final models of the Post versus Pre FDCAs introduction for the presence of each definition of resistance or genotypical mutation adjusted for all co-variables dConsidered as triple-class drug resistance eIn addition of other co-variables, we included in the regression model the exposure to: azt, ddi, 3tc, d4t, tnf, abc, and ftc, as independent co-variables fIn addition of other co-variables, we included in the regression model the exposure to: efv and nvp, as independent co-variables. gIn addition of other co-variables, we included in the regression model the exposure to: idv, rtv, sqv, nfv, apv, lpv, tpv, atv and fosapv as independent co-variables,

Table 3: Association of Class Resistances and Resistance Associated Mutations with FDCAs Perioda in a multivariate logistic regression analysisb.

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