Parameter HIV-negative CD4>200 CD4<200 CD4<200, HAART
n-value 22 20 12 11
Age (mean/range) 26/21-33 28/19-46 36/20-57 45/35-59
Gender (M/F) 13/9 19/1 11/1 11/0
Ethnicity(A/B/H/W) 10/0/0/12 0/13/0/7 0/7/0/5 0/3/2/6
HAART - - - 6-12 months
Pre-HAART viral load      -  - - 505,476 ± 230,034
Day 0 viral load 0# 47,160 ± 25,845# 1,066,177 ± 515,031 12,158 ± 12,011#
Nadir CD4 - 553 ± 54*,# 109 ± 26 69 ± 23
Vax CD4, #/ml [%] - 553*,# [30.5]*,# 126 [7.8] 206 [12.6]
CD19+ B cells, % 9.5 ± 0.6  8.7 ± 0.8 12.4 ± 1.9 9.2 ± 1.3
CD19+ B cells, #/ml 166.5 ± 21.5 166.5 ± 19.3  127.3 ± 13.3    114.0 ± 19.3
Unselected CD19+ B cell subsets, %
IgM+ Memory 12.5 ± 1.1* 13.5 ± 1.6* 7.9 ± 2.7 5.8 ± 1.2
Switched Memory 16.3 ± 1.6* 15.9 ± 2.0* 10.0 ± 3.2 7.0 ± 0.9
Naïve 71.2 ± 2.5* 70.6 ± 2.7* 82.0 ± 4.6 87.2 ± 1.5
Unselected CD19+ B cell subsets, #/ml
IgM+ Memory 17.2 ± 2.1*,# 22.0 ± 3.3* 11.1 ± 3.2 8.4 ± 2.6
Switched Memory 24.4 ± 6.5* 30.3 ± 6.9 12.5 ± 4.6 7.4 ± 1.3
Naïve 124.9 ± 16.5 114.2 ± 12.6 103.7 ± 14.1 98.2 ± 13.7
Viral loads are reported as copies/ml. Vax: Value at time of vaccination, A: Asian, B: Black, H: Hispanic, W: White. Data are mean ± standard error of the mean. * indicates significant difference (p<0.05) compared to the CD4<200, HAART group. # indicates significant differences (p<0.05) compared to the CD4<200 group.
Table 1: Study population and unselected CD19+ B cell percentages and counts.
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