| Parameter |
HIV-negative |
CD4>200 |
CD4<200 |
CD4<200, HAART |
| n-value |
22 |
20 |
12 |
11 |
| Age (mean/range) |
26/21-33 |
28/19-46 |
36/20-57 |
45/35-59 |
| Gender (M/F) |
13/9 |
19/1 |
11/1 |
11/0 |
| Ethnicity(A/B/H/W) |
10/0/0/12 |
0/13/0/7 |
0/7/0/5 |
0/3/2/6 |
| HAART |
- |
- |
- |
6-12 months |
| Pre-HAART viral load |
- |
- |
- |
505,476 ± 230,034 |
| Day 0 viral load |
0# |
47,160 ± 25,845# |
1,066,177 ± 515,031 |
12,158 ± 12,011# |
| Nadir CD4 |
- |
553 ± 54*,# |
109 ± 26 |
69 ± 23 |
| Vax CD4, #/ml [%] |
- |
553*,# [30.5]*,# |
126 [7.8] |
206 [12.6] |
| CD19+ B cells, % |
9.5 ± 0.6 |
8.7 ± 0.8 |
12.4 ± 1.9 |
9.2 ± 1.3 |
| CD19+ B cells, #/ml |
166.5 ± 21.5 |
166.5 ± 19.3 |
127.3 ± 13.3 |
114.0 ± 19.3 |
| Unselected CD19+ B cell subsets, % |
| IgM+ Memory |
12.5 ± 1.1* |
13.5 ± 1.6* |
7.9 ± 2.7 |
5.8 ± 1.2 |
| Switched Memory |
16.3 ± 1.6* |
15.9 ± 2.0* |
10.0 ± 3.2 |
7.0 ± 0.9 |
| Naïve |
71.2 ± 2.5* |
70.6 ± 2.7* |
82.0 ± 4.6 |
87.2 ± 1.5 |
| Unselected CD19+ B cell subsets, #/ml |
| IgM+ Memory |
17.2 ± 2.1*,# |
22.0 ± 3.3* |
11.1 ± 3.2 |
8.4 ± 2.6 |
| Switched Memory |
24.4 ± 6.5* |
30.3 ± 6.9 |
12.5 ± 4.6 |
7.4 ± 1.3 |
| Naïve |
124.9 ± 16.5 |
114.2 ± 12.6 |
103.7 ± 14.1 |
98.2 ± 13.7 |
Viral loads are reported as copies/ml. Vax: Value at time of vaccination, A: Asian, B: Black, H: Hispanic, W: White. Data are mean ± standard error of the mean. * indicates
significant difference (p<0.05) compared to the CD4<200, HAART group. # indicates significant differences (p<0.05) compared to the CD4<200 group. |
