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Figure 3: Comparative analysis of post-vaccination PPS-specific B cell response in long term HAART cohorts versus HIV negative volunteers
Panel A-B: Post vaccination (Day 7) PPS14 (A) and 23F (B) -specific switched and IgM memory B cell percentages were compared between HIV-negative volunteers
(n=22, black bars), group A (n=29, slanted stripes) and group B (n=10, horizontal stripes). Panel C-D: Post vaccination PPS14 (C) and 23F (D) -specific switched and IgM memory B cell numbers were compared between HIV-negative volunteers (n=22, black bars) compared to group A (n=29, slanted stripes) and group B (n=10, horizontal stripes).100,000 events were recorded for each sample. Group comparisons were performed using analysis of variance (ANOVA) with Tukeys post-hoc test.Data are represented as mean ± standard errors of the mean (SEM). *p<0.05, **p<0.01, ***p<0.001. |