| Parameters |
Group A (CD4>200) |
Group B (CD4<200) |
| n value |
29 |
10 |
| Age(years) |
49 |
50 |
| Sex, no. male/no. female |
24/5 |
10/0 |
| Race: White/Black/Hispanic/Asian |
21/8/0/0 |
4/5/1/0 |
| HAART status |
|
|
| At the time of primary vaccination |
No |
No |
| At the time of re-vaccination (current study) |
≥5 years |
≥5 years |
| Viral Load |
|
|
| At the time of revaccination (current study) |
≤40 copies/ml |
≤40 copies/ml |
| PPV vaccination history |
|
|
| Primary Vaccination |
Yes (≥5 years ago) |
Yes (≥5 years ago) |
| Revaccinated (for the current study) |
Yes |
Yes |
| CD4 count (cells/mm3) |
|
|
| Nadir CD4 history |
≤200 |
≤200 |
CD4 count at the time
of re-vaccination |
≥200 |
≤200 |
Total CD19+ B cells¥
Percentage (%)
Cells count (cells/µl) |
8.5 ± 0.6
148±15 |
10.8 ± 1.4
151±33 |
| Unselected CD19+ B cell subset percentage (%)¥ |
|
|
1. Switched Memory (CD27+ IgM-)
2. IgM memory (CD27+ IgM+)
3. Naive (CD27-IgM +/-) |
15.74 ± 1.68
9.23 ± 1.39
76.44 ± 2.48 |
12.79 ± 3.13
7.81 ± 1.51
79.39 ± 3.88 |
Unselected CD19+ B cell subset count (cells/µl) ¥ €
1.Switched Memory (CD27+IgM-)
2.IgM memory (CD27+ IgM+)
3.Naive (CD27-IgM +/-) |
23 ± 3
13±2
114 ±14 |
20 ± 6
10± 3
122 ± 29 |
¥ Data are represented as mean ± standard error of the mean (SEM). € Cell counts of specific cell population in donor groups are reported as the average value of =
[(percentage of specific cell population) * total lymphocytes/ml] for that group