| A. Switched Memory B cell subset distribution (%) |
| Patient groups |
PPS14- (Unselected) |
PPS14+ (Selected) |
PPS23F- (Unselected) |
PPS23F+ (Selected) |
| Group A (CD4>200) |
15.7±1.6 |
25.69±2.75*** |
15.74±1.68 |
29.62±2.89*** |
| Group B (CD4<200) |
12.76+2.81 |
21.78+6.19 |
12.79±3.13 |
27.59±5.77* |
| B. IgM Memory B cell subset distribution |
| Patient groups |
PPS14- (Unselected) |
PPS14+ (Selected) |
PPS23F- (Unselected) |
PPS23F+ (Selected) |
| Group A (CD4>200) |
9.30±1.39 |
32.84±3.88*** |
9.23±1.36 |
39.18±3.12*** |
| Group B (CD4<200) |
8.16±1.79 |
31.34±4.71** |
7.81±1.51 |
42.87±5.43*** |
| C. Naive B cell subset distribution |
| Patient groups |
PPS14- (Unselected) |
PPS14+ (Selected) |
PPS23F- (Unselected) |
PPS23F+ (Selected) |
| Group A (CD4>200) |
74.98±2.38 |
41.46±3.56*** |
76.24±2.48 |
31.25±2.66*** |
| Group B (CD4<200) |
79.0±3.81 |
46.87±6.34*** |
79.39±3.88 |
26.23±6.97*** |
Data are mean ± standard error of the mean. * indicates significant difference in the PPS-selected population post vaccination (day 7) levels compared to unselected B
cells within a group. Pre to post vaccination changes in a single group were compared using paired t-test and between groups were compared using ANCOVA.*p<0.05,
**p<0.01, ***p<0.001. |
