VLP-ELISA* NA-HPV** NA-PsV** HPV16 HPV16 HPV16 Positive Negative Positive Negative Positive Negative HPV18  Negative 11 2 22 19 11 9 Positive 22 59 26 27 14 60 Seroprevalence         HPV16 35% 51% 27%       HPV18 14% 44% 21% Cross-reactivity   Kappa coefficients† 0.35 (0.16, 0.53) 0.04 (-0.15, 0.24) 0.33 (0.11, 0.54)

*Definition of seropositive for VLP-ELISA: If the mean VLP OD value is significantly higher than the mean CRPV OD value (at p-value<0.05), the serum is defined as seropositive. **Definition of seropositive for NA-HPV and NA-PsV: If the relative infectivity value is ≤ 0.5 compared with the negative control (representing a 50% or more reduction in infectivity), the serum is defined as seropositive. † Kappa coefficients are used to assess the cross-reactivity, which is represented by the degree of agreement between two tests (HPV16 and HPV18). Kappa value ranges from 0 or <0 (a lack of agreement or a purely random coincidence) to 1 (a perfect agreement).

Table 1: Results of HPV16 or HPV18 antibody detected by the 3 assays among 94 HIV-infected women.

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