Lumbar spine Z-score Femoral  neck  Z-score HIV mono-infected  n = 129 HIV/HCV co-infected n = 65 HIV mono-infected  n = 129 HIV/HCV co-infected n = 65   Analysis Analysis Analysis Analysis Univariate Multivariate Univariate Multivariate Univariate Multivariate Univariate Multivariate Demographic/lifestyle characteristics   P< β P<   P< β P<   P< β P<   P< β P<       Age 0.03* ns - - -0.12* ns - - -0.18* ns - - -0.17 ns - -       BMI (kg/m2) 0.25* 0.01 0.30 0.01 0.05* ns - - 0.44* 0.0001 0.45 0.0001 0.26* 0.05 0.33 0.02       Menopause 0.02° ns - - -0.02° ns - - -0.06° ns - - -0.18° ns - - Biochemical parameters   Bone alkaline phosphatase  (IU/L) -0.01* ns - - -0.25* 0.05 - - -0.25* 0.01 - - -0.31* 0.02 - -      HDL-cholesterol (mg/dL ) 0.2* 0.03 0.22 0.02 0.09* ns - - 0.01 ns - - 0.12* ns - - Characteristics of HIV infection       Nadir CD4+ < 200 (cells/μL) -0.21° 0.05 - - -0.03° ns - - -0.28° 0.01 - - -0.17° ns - -       Time since HIV  diagnosis -0.03* ns - - -0.2* ns - - -0.02* ns - - -0.04* ns - -       Score of PI exposure -0.09° ns - - -0.19° ns - - -0.2° 0.02 - - -0.27° 0.04 -0.32 0.02 HIV: Human Immunodeficiency Virus; HCV: Hepatitis C Virus; DXA: Dual-Energy X-Ray Absorptiometry; BMI: Body Mass Index; Ns: Not Significant; HDL: High-Density Lipoprotein; PI: Protease Inhibitor. *R: Pearson’s Correlation Test; °Spearman’s Rank Correlation Test.

Table 4: Correlation between lumbar spine, femoral neck DXA Z-scores and the study parameters.

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