| |
Lumbar Spine T-score |
Femoral neck T-score |
| HIV mono-infected n = 129 |
HIV/HCV co-infected n = 65 |
HIV mono-infected n = 129 |
HIV/HCV co-infected n = 65 |
| |
Analysis |
Analysis |
Analysis |
|
| Univariate |
Multivariate |
Univariate |
Multivariate |
Univariate |
Multivariate |
Univariate |
Multivariate |
| Demographic/lifestyle characteristics |
|
P< |
β |
P< |
|
P< |
β |
P< |
|
P< |
β |
P< |
|
P< |
β |
P< |
| Age |
-0.24* |
0.01 |
- |
- |
-0.16 |
ns |
- |
- |
-0.22 |
0.01 |
- |
- |
-0.18* |
ns |
- |
- |
| BMI (kg/m2) |
0.17* |
Ns |
- |
- |
0.15* |
ns |
- |
- |
0.25* |
0.01 |
- |
- |
0.27* |
0.04 |
0.36 |
0.03 |
| Menopause |
-0.04° |
ns |
- |
- |
-0.3° |
0.02 |
- |
- |
-0.03° |
ns |
- |
- |
-0.27° |
0.04 |
- |
- |
| Biochemical parameters |
| Bone alkaline phosphatase
(IU/L) |
-0.3* |
0.01 |
- |
- |
-0.26* |
0.05 |
- |
- |
-0.28* |
0.02 |
- |
- |
-0.34* |
0.02 |
- |
- |
| HDL-cholesterol (mg/dL ) |
0.08* |
ns |
- |
- |
0.07* |
ns |
- |
- |
0.04* |
ns |
- |
- |
0.11* |
ns |
- |
- |
| Characteristics of HIV infection |
| Nadir CD4+ < 200
(cells/μL) |
-0.22° |
0.03 |
- |
- |
-0.17° |
ns |
- |
- |
-0.28° |
0.01 |
- |
- |
-0.17° |
ns |
- |
- |
| Time since HIV
diagnosis |
-0.20* |
0.03 |
- |
- |
-0.14* |
ns |
- |
- |
-0.14* |
ns |
- |
- |
-0.05* |
ns |
- |
- |
| Score of PI exposure |
-0.2° |
0.02 |
-0.33 |
0.02 |
-0.25° |
0.05 |
- |
- |
-0.25° |
0.01 |
-0.5 |
0.0001 |
-0.4° |
0.02 |
-0.32 |
0.02 |
HIV: Human Immunodeficiency Virus; HCV: Hepatitis C Virus; DXA: Dual-Energy X-Ray Absorptiometry; BMI: Body Mass Index; Ns: Not Significant; HDL: High-Density
Lipoprotein; PI: Protease Inhibitor. *R: Pearson’s Correlation Test; °Spearman’s Rank Correlation Test.