Treatment Group Ad5 nAb* N** Injection schedule months (days)
0 (0) 1 (28) 2 (56) 6 (168)
1 <18 34/6 rAd5 - - rAd5
2 <18 48/8 DNA DNA DNA rAd5
3 <18 48/8 DNA DNA DNA rAd35
4 ≥18 34/6 DNA DNA DNA rAd35
Total   192 164/28        
*Adenovirus 5 (Ad5) neutralizing antibody (nAb) ≥ 18 represents Ad5 seropositive individuals; **N represents the active vaccinees/placebo recipients who were blinded to treatment assignment within each treatment group. DNA vaccinations were delivered by Biojector, and adenovectors were delivered by needle and syringe. Groups 2 and 3 were blinded to assignment to these groups.
Table 1: HVTN 077 Protocol Schema.
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