Variable values

            Laboratory  characteristics

Serum alanine transaminase (i.u/L)

Serum creatinine (mmol/L)

Hemoglobin (g/dL)

White cell count (x109 cells/L)

Absolute neutrophil count (x109 cells/L)

Platelet count (103/mm3)

Normal reference value

12-40

120-1470

10-14g

4.5 -10.0

1.4 – 1.6

150-400 

Median baseline value (range)

23
(6.7-43.0)

34
(10-130)

11.3
 (10-15)

5.2 (2.9-8.1)

2.2
(1.3-3.3 )

207
(148-490)

Median value with ART (range)

85.3
(40—444.2)

245.5
(120-1470)

6.3 (2.0-9.9)

3.4
(0.85-4.9)

1.0
(0.4-2.0)

80
(68.3-125)

 P-value

 0.00

 0.00

0.02

 0.00

0.04

0.00

Toxicity grade
[reference value]

1
[50—103]

2
[170-390]

4
[ <6.5]

2
[3.0 – 3.5]

1
[1.0-1.3]

2
[50—75]

Number of patients (%)

103 (28.9)

53 (14.8)

56 (15.7)

68 (19.1)

69 (19.3)

8 (2.2)