Naïve patients (N=407) Switch (N=696) Failure (N=601)
Treatment duration before discontinuation [0-6[ months (N=93) ≥ 6 months (N=55) Total (N=148) [0-6[ months (N=93) ≥ 6 months (N=73) Total (N=166) [0-6[ months (N=120) ≥ 6 months (N=131) Total (N=251)
Intolerance, N (%) 47 (11.5) 9 (2.5) 56 (14) 68 (10) 22 (3) 90 (13) 65 (11) 23 (4) 88 (15)
Suspected hypersensitivity, N (%) 27 (6.6) 3 (0.7) 30 (7.3) 40 (5.7) 2 (0.3) 42 (6) 46 (7.6) 2 (0.3) 48 (7.9)
Treatment failure, N (%) 6 (2) 17 (4) 23 (6) 2 (1) 16 (2) 18 (3) 7 (1) 66 (11) 73 (12)
Other, including non adherence, N (%) 40 (10) 29 (7) 69 (17) 23 (3.3) 35 (5) 58 (8.3) 48 (8) 42 (7) 90 (15)
Table 2: Reasons for treatment discontinuation across the groups and the treatment duration.
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