Case (Ref)

Phosphorus (2.2-5.1 mg/dL)

Phos
(post)

Bicarbonate (22-30 mEq/mL)

ALP (25-123 IU/L)

ALP
(post)

BMD (gm/cm2) L-spine, hip

BMD (T-score) L-spine, hip

Creatinine baseline/peak /post (0.4-1.1 mg/dL)

GFR mL/min (method)

Hypokalemia

Glucosuria, Proteinuria

Vitamin D deficiency (1,25 or 25-OH)

1 [3]

2.6

NL

14

516

N/A

N/A

N/A

1.3/2.0/NL

24-31 (CG)

N/A

Both

Yes (25-OH)

2 [4]

1.8

NL

22.5

341

N/A

.899/.631

-2.3, -3.1

1.1/1.3/NL

33 (N/A)

Yes

Both

No

3 [12]

1.3

NL

20

358

NL

N/A

-1.4

0.7/1.9/NL

N/A

No

Both

N/A

4 [13]

1.4

NL

20

310

170

N/A

N/A

0.8/3.9/NL

N/A

Yes

Both

No

5 [13]

1.3

N/A

N/A

3194

 

N/A

N/A

0.8/1.1

N/A

N/A

N/A, Yes

N/A

6 [14]

1.5

NL

N/A

N/A

N/A

N/A

N/A

N/A/1.5/NL

39 (M)

N/A

Both

Yes (25-OH)

7 (case 1)

1.5

3.3

19

168

74

N/A

-1.9, -2.5

0.8/1.4/1.0

43

Yes

Yes, N/A

No

8 (case 2)

1.8

3.7

20

413

300

N/A

-2.7, -1.9

0.8/1.3/1.11

44

No

Both

Yes

9 (case 3)

1.4

3.0

21

221

63

1.04/.68

-1.7, -2.9

1.1/1.6/1.5

41 (O)

No

Both

N/A

Abbreviations: ALP=Alkaline Phosphatase; BMD=Bone Mineral Density; GFR=Glomerular Filtration Rate; N/A=Not Available; NL=within Normal Limits, In GFR; M=MDRD; CG=Cockcroft-Gault; O=Other
Table 2: Laboratory Findings in patients with TDF-associated osteomalacia.
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