Category Odds Ratio (95% CI) P value Normal BMI (18.5-24.49 m/kg2) 1.00          vs. Underweight (<18.5 m/kg2) 1.05 (0.90-1.22) 0.010        vs. Overweight (25-29.99 m/kg2) 1.12 (0.99-1.26)          vs. Obese (≥30 m/kg2) 1.25 (1.10-1.42)   Female 1.00 0.002        vs. Male 0.85 (0.77-0.95)   Non-smoker 1.00 0.005        vs. Current smoker 1.13 (1.002-1.28)          vs. Ex-smoker 0.91 (0.80-1.03)   Year of step-down date (later vs. earlier) 0.88 (0.84-0.93) <0.001 No GERD diagnosis and/or drugs 1.00 <0.001        vs. GERD diagnosis and/or drugs 1.39 (1.23-1.58)   0-1 SABA prescriptions/years 1.00 <0.001        vs. 2-3/years 1.03 (0.92-1.16)          vs. 4-6/years 1.14 (0.996-1.31)          vs. ≥7/years 1.41 (1.22-1.62)   0-3 primary care consultations/years 1.00 <0.001        vs. 4-5/years 1.27 (1.09-1.47)          vs. 6-8/years 1.31 (1.14-1.52)          vs. 9-13/years 1.73 (1.49-1.99)          vs. ≥14/years 1.82 (1.55-2.14)   *Composite database measure (defined in text) BMI: Body Mass Index; GERD: Gastroesophageal Reflux Disease; ICS: Inhaled Corticosteroid; SABA: Short-acting β-Agonist

Table 4: Demographic and baseline factors predictive of loss of asthma control during the year after ICS dose step-down for all patients in the ICS cohorts who met the composite database measure of no loss of asthma control* during the baseline year (n=18,015): A multivariate model.

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