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| Figure 8: The contractile capacity of ASM is not fixed. Many mediators that are often times dysregulated in asthmatic lungs (enumerated in the middle column) have been shown to increase the contractile capacity of ASM. This suggests that, although heterogeneous between affected individuals, the inflammatory milieu of anyone asthmatic is likely to possess mediators that are capable render ASM hypercontractile. This acquired hypercontractility can, in turn, contribute to the transient component of AHR [27]. |
