1. Absence of pre-existing respiratory disorder, asthma symptomatology or a history of asthma in remission and exclusion of conditions that can simulate asthma
2. Onset of asthma after a single exposure or accident.
3. Exposure is to an irritant vapor, gas, fumes or smoke in very high concentrations.
4. Onset of asthma occurs within minutes to hours and always less than 24 hours after the exposure.
5. Finding of a positive methacholine challenge test (<8 mg/ml) following the exposure.
6. Possible airflow obstruction on pulmonary function testing.
7. Another pulmonary disorder to explain the symptoms and findings is excluded
Table 1: Diagnostic Criteria for RADS
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