Groups Macroscopic findings Microscopic findings Inoculation site Liver Inoculation site Liver Control s.c Absence of visible tisular alterations Absence of visible tisular alterations Absence of inflammatory infiltrate or others microscopic  alterations Absence of alterations  in the hepatic tissue Control i.m Absence of visible tisular alterations Absence of visible tisular alterations Absence of inflammatory infiltrate or others microscopic  alterations Absence of alterations  in the hepatic tissue Acetam - Moderate irregular  liver's yellowish coloration - Focus of  necrosis parenchymal, degenerated parenchymal  hepatocytes multizonal, vascular congestion and swelling of hepatocytes FA s.c Nodule >5 mm, large amount of white tissue and haemorrhagic zones Absence of visible tisular alterations Severe  diffuse inflammation, necrotising granuloma Absence of alterations  in the hepatic tissue FA i.m Localized nodular Inflammatory zone Absence of visible tisular alterations Inflammation with necrotising granuloma Absence of alterations  in the hepatic tissue   Acetam/ FA s.c   Nodule >5 mm, large amount of white tissue and haemorrhagic zones   Light liver'syellowishcoloration   Severe diffuse inflammation necrotising granuloma   Light  degenerated parenchymal hepatocytes, with very scarce and little necrosis focus   Acetam/ FA s.c   Localized nodular Inflammatory zone   Light liver'syellowishcoloration   Inflammation with necrotising granuloma   Light  degenerated parenchymal hepatocytes, with scarce necrosis focus

Table 2: Main pathological finding at injection sites and liver of treated mice groups (n=5).

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