Stage 1a Stage 2 Stage 3 Stage 4 Total Codon 16 polymorphism Arg/Arg            Frequency 3 2 6 3 14 Percentb 2.91% 1.94% 5.83% 2.91% 13.59%             Arg/Gly            Frequency 7 11 25 9 52  Percent 6.80% 10.68% 24.27% 8.74% 50.49%             Gly/Gly            Frequency 3 12 16 6 37  Percent 2.91% 11.65% 15.53% 5.83% 35.92%             Total            Frequency 13 25 47 18 103  Percent 12.62% 24.27% 45.63% 17.48% 100.00% Codon 27 polymorphism Gln/Gln            Frequency 5 6 17 5 33  Percent 4.85% 5.83% 16.50% 4.85% 32.04%             Gln/Glu            Frequency 6 14 24 9 53  Percent 5.83% 13.59% 23.30% 8.74% 51.46%             Glu/Glu            Frequency 2 5 6 4 17  Percent 1.94% 4.85% 5.83% 3.88% 16.50%             Total           Frequency 13 25 47 18 103  Percent 12.62% 24.27% 45.63% 17.48% 100.00%

aStage 1-4 corresponds to mild intermittent, mild persistent, moderate persistent, and severe persistent bDerived from frequency divided by total number of subjects (103). e.g., Arg/Arg Stage 1: 3/103 = 2.91%

Table 5: Distribution of codon 16 and codon 27 polymorphisms by asthma stage

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