Stage 1a Stage 2 Stage 3 Stage 4 Total
Codon 16 polymorphism Arg/Arg          
 Frequency 3 2 6 3 14
Percentb 2.91% 1.94% 5.83% 2.91% 13.59%
           
Arg/Gly          
 Frequency 7 11 25 9 52
 Percent 6.80% 10.68% 24.27% 8.74% 50.49%
           
Gly/Gly          
 Frequency 3 12 16 6 37
 Percent 2.91% 11.65% 15.53% 5.83% 35.92%
           
Total          
 Frequency 13 25 47 18 103
 Percent 12.62% 24.27% 45.63% 17.48% 100.00%
Codon 27 polymorphism Gln/Gln          
 Frequency 5 6 17 5 33
 Percent 4.85% 5.83% 16.50% 4.85% 32.04%
           
Gln/Glu          
 Frequency 6 14 24 9 53
 Percent 5.83% 13.59% 23.30% 8.74% 51.46%
           
Glu/Glu          
 Frequency 2 5 6 4 17
 Percent 1.94% 4.85% 5.83% 3.88% 16.50%
           
Total          
Frequency 13 25 47 18 103
 Percent 12.62% 24.27% 45.63% 17.48% 100.00%
aStage 1-4 corresponds to mild intermittent, mild persistent, moderate persistent, and severe persistent
bDerived from frequency divided by total number of subjects (103). e.g., Arg/Arg Stage 1: 3/103 = 2.91%
Table 5: Distribution of codon 16 and codon 27 polymorphisms by asthma stage
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