Stage 1a Stage 2 Stage 3 Stage 4 Total
Codon 16 polymorphism Arg/Arg          
 Frequency 4 3 5 2 14
Percentb 3.88% 2.91% 4.85% 1.94% 13.59%
           
Arg/Gly          
 Frequency 15 21 11 5 52
 Percent 14.56% 20.39% 10.68% 4.85% 50.49%
           
Gly/Gly          
 Frequency 9 15 9 4 37
 Percent 8.74% 14.56% 8.74% 3.88% 35.92%
           
Total          
 Frequency 28 39 25 11 103
 Percent 27.18% 37.86% 24.27% 10.68% 100.00%
Codon 27 polymorphism Gln/Gln          
 Frequency 8 13 9 3 33
 Percent 7.77% 12.62% 8.74% 2.91% 32.04%
           
Gln/Glu          
 Frequency 15 20 13 5 53
 Percent 14.56% 19.42% 12.62% 4.85% 51.46%
           
Glu/Glu          
 Frequency 5 6 3 3 17
 Percent 4.85% 5.83% 2.91% 2.91% 16.50%
           
Total          
Frequency 28 39 25 11 103
 Percent 27.18% 37.86% 24.27% 10.68% 100.00%
aStage 1-4 corresponds to GOLD COPD Stage I-IV
bDerived from frequency divided by total number of subjects (103). e.g., Arg/Arg Stage 1: 4/103=3.88%
Table 6: Distribution of codon 16 and codon 27 polymorphisms by COPD stage.
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