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Papulopustular (acneiform) rash |
Maculo-papular rash |
Hand-foot syndrome |
| Grade 1 |
<10% body-surface area, with or without symptoms of pruritus or tenderness |
<10% body-surface area, with or without symptoms (e.g. pruritus, tightness, or burning) |
Minimal skin changes (e.g., erythema, edema, or hyperkeratosis) without pain |
| Grade 2 |
10–30% body-surface area, with or without symptoms of pruritus or tenderness; with psychosocial impact; limiting instrumental activities of daily living |
10–30% body-surface area with or without symptoms (e.g. pruritus, tightness, or burning), limiting instrumental activities of daily living |
Skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting practical activities |
| Grade 3 |
>30% body-surface area, with or without symptoms of pruritus or tenderness; limiting self-care activities of daily living; associated with local superinfection with oral antibiotics indicated |
>30% body-surface area with or without associated symptoms; limiting self-care activities of daily living |
Severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self-care activities |
| Grade 4 |
Covering any percent of the body-surface area; with or without symptoms of pruritus or tenderness; associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences |
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| Grade 5 |
Death |
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