Papulopustular (acneiform) rash Maculo-papular rash Hand-foot syndrome
Grade 1 <10% body-surface area, with or without symptoms of pruritus or tenderness <10% body-surface area, with or without symptoms (e.g. pruritus, tightness, or burning) Minimal skin changes (e.g., erythema, edema, or hyperkeratosis) without pain
Grade 2 10–30% body-surface area, with or without symptoms of pruritus or tenderness; with psychosocial impact; limiting instrumental activities of daily living 10–30% body-surface area with or without symptoms (e.g. pruritus, tightness, or burning), limiting instrumental activities of daily living Skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting practical activities
Grade 3 >30% body-surface area, with or without symptoms of pruritus or tenderness; limiting self-care activities of daily living; associated with local superinfection with oral antibiotics indicated >30% body-surface area with or without associated symptoms; limiting self-care activities of daily living Severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self-care activities
Grade 4 Covering any percent of the body-surface area; with or without symptoms of pruritus or tenderness; associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences    
Grade 5 Death    
Table 2: Classification of severity of cutaneous adverse events (as defined by the National Cancer Institute Common Toxicity Criteria, version 4.03).
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