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Figure 1: Glucagon reduces plasma insulin levels, peritoneal and mesenteric mast cell numbers, and mast cell reactivity in vitro.
Glucagon (10 or 100μg/Kg, i.p.) was administered once a day for 7 days in male Swiss-Webster mice. Then, plasma insulin levels, peritoneal and mesenteric mast cell numbers were evaluated (A, B and C, respectively). Data are expressed as mean ± S.E.M. of 6 animals. * P< 0.05 as compared to untreated mice. (D) Hypodermic tissue was removed from actively sensitized rats and challenged with OVA (300 μg/ml) in vitro during 1h, and supernatant was recovered to histamine evaluation by fluorescence. Treatment with glucagon (0.1 or 1 μM) was realized in vitro 1h before challenge. Data are expressed as mean ± S.E.M. of 4 replicates. +P< 0.05 as compared to nonchallenged tissue; #P< 0.05 as compared to ovalbumin-challenged tissue.
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