Publication

Target

Omega 3 supplementation
Intake (from/until)

Study

Findings&Summary

Dunstan et al.  [54] pregnant women
with family history of allergic disease
Fish oil (3.7 g/d n-3 PUFA)
20 w gestation/ until birth
RDBPC Infants were less likely to have a positive skin prick test to egg  vs placebo (OR 0,34) at 1 y
Lauritzen et al. [55] Pregnant women with a fish intake below the population median Fish oil (1.5 g/d of n-3 PUFA)
4 mon of lactation
RDBPC No difference in atopic disease and plasma IgE between active and placebo groups
Furuhjelm et al.
(2009) [56]   (2011) [57]
pregnant women
with either personal or family history of allergic disease
1.6 g eicosapentaenoic ac. + 1.1 g docosahexaenoic ac./daily.
25 w gestation/
3-4 m postnatally
RDBPC No effect on the prevalence of clinical symptoms of allergic disease, but a decrease in cumulative incidence of IgE-associated disease during the 1st y. Decrease in cumulative incidence of IgE-associated disease still remained until 2 y of age
Palmer et al. [58] pregnant women
with family history of allergic disease
fish oil (900 mg/d n-3 PUFA)
21 w gestation/ until birth
RDBPC No differences in the overall percentage of infants with Ig E associated food allergy versus placebo.
Table 2: Clinical trials assessing the preventive effect of n-3 PUFA supplementation during pregnancy in food allergy in infants at high risk of atopy [53].
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