Publication Target Probiotic Intake (from/until) Study Findings and Summary
Kim et al. [79] pregnant women
with family history of allergic disease
Mixture of 2 strains
32 w.gestation/ 3m postnatally
RDBPC No difference in food sensitization or probable food allergy in treatment
versus placebo groups after 1 year
Niers et al. [78] pregnant women
with family history of allergic disease
Mixure of 3 strains
34 w.gestation/ 12m postnatally
RDBPC No difference in food sensitization in treatment versus placebo after 1 & 2y.
Boyle et al. [81] pregnant women
with family history of allergic disease
Lactobacillus GG
36 w.gestation/ until delivery
RDBPC No difference in food sensitization in treatment versus placebo after 1 year
Dotterud et al. [80] Nonselected maternal population Mixure of 3 strains
36th w.gestation/ 3m postnatally
RDPPC Reduced cumulative incidence of atopic dermatitis, but no effect on atopic sensitization
Kuitunen et al.
(2009) [83] Kukkonen et al. (2011) [84] Kuitunen et al. (2012) [85]
pregnant women
with family history of allergic disease same cohort same cohort
Mixure of 4 strains
36 w.gestation/ 6m postnatally
RDPPC No difference in cumulative incidence of allergic diseases and IgE sensitization versus placebo at 5 y. No difference on serum food-specific IgA, IgG1 or IgG4 concentrations versus placebo at age 2y Increased IL-10 and decreased casein IgA Abs in breast milk from mothers treated with probiotic vs placebo.
Ou et al. [82] pregnant women
with personal history of allergic disease
Lactobacillus GG
24 w.gestation/ until delivery
RDPPC Reduced severity of maternal allergic disease but not the incidence of childhood allergic disease.
Table 3: Clinical studies assessing the preventive effect of probiotic intake during pregnany/lactation in children’s food allergy [95].
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