Conditions Nominal
concentration
(ng/mL)
Observed concentration (ng/mL) Difference (%)
between reference
and test
Mean of reference
(n=6)
Mean of test (n=6)
Storage of samples at
room temperature for 18 hr
6 5.5 5.2 -5.4
1600 1430.7 1363.0 -4.7
Three freeze-thaw cycles (- 70°C) 6 6.0 5.8 -3.3
1600 1500.8 1491.0 -0.7
Storage of extracted samples
in autosampler at 4°C for 36 hr 
6 6.2 6.3 1.6
1600 1624.3 1612.0 -0.8
Table 2: Stability of ticlopidine in human plasma under various conditions.
Goto home»