| Kinetic parameters |
Healthy |
Mastitic |
P value |
| Cmmax (μg/ml) |
14.75 ± 0.95 |
17.01 ± 0.67 |
0.11 NS |
| t1/2β(h) |
4.61 ± 0.76 |
7.28 ± 0.09 |
0.00** |
| Vdarea(L/kg) |
0.95 ± 0.05 |
1.05 ± 0.05 |
0.23NS |
| AUC(mg/L.h) |
82.18 ± 2.78 |
101.49 ± 6.23 |
0.03* |
| MRT |
7.10 ± 0.20 |
10.63 ± 0.30 |
0.00** |
| ClB(ml/kg/min) |
2.04 ± 0.07 |
1.67 ± 0.09 |
0.01* |
| Tmax (h) |
0.58 ± 0.05 |
0.47 ± 0.03 |
0.09NS |
NS = Non significant; *P < 0.05; **P < 0.01.
Cmmax = maximumr milk concentration; t1/2βM = elimination half-life in milk; VdareaM
= volume of distribution based on area under curve in milk; AUC= area under the
curve; MRT = Mean residence time; ClBM, =total clearance in milk and TmaxM = time
to peak concentration in milk |
