Kinetic Parameters

Without meloxicam

With meloxicam

t-value

A(µg/ml)

5.59±0.26

4.97±0.29

1.48 NS

B(µg/ml)

4.79±0.25

4.38±0.35

0.88 NS

C°p(µg/ml)

10.38±0.43

9.35±0.62

1.26 NS

α(h-1)

2.22±0.21

2.97±0.51

1.24 NS

β(h-1)

0.26±0.01

0.26±0.01

0.28 NS

t½α(h)

0.27±0.05

0.23±0.05

0.51 NS

t½β(h)

2.73±0.12

2.70±0.13

0.15 NS

AUC(mg/L.h)

20.51±1.47

17.72±1.40

1.26 NS

AUMC(mg/L.h)

76.56±8.99

66.94±7.16

0.76 NS

MRT(h)

3.65±0.21??

3.73±0.18

0.27 NS

ClB(ml/kg/min)

8.41±0.66

9.79±0.84

1.19 NS

Vdarea(L/kg)

1.95±0.08

2.26±0.15

1.65 NS

K12(h-1)

0.84±0.12

1.22±0.26

1.20 NS

K21(h-1)

1.15±0.08

1.51±0.23

0.32 NS

K2(h-1)

0.48±0.03

0.50±0.02

0.41 NS

T/P

0.91±0.06

0.94±0.06

0.28 NS


NS=Non Significant
Table 1: Comparative mean pharmacokinetic profile of ENR after single dose (10mg/kg) i.v. administration with and without MLX (1mg/kg, i.v.) in turkeys.
Goto home»