Captopril concentration in whole blood (ng/ml)

Analytical Method

Mean concentration found ±SD
(ng/ml) (n=6)

Precision
(% RSD)

Accuracy (%bias)

400

LC-MS(SIM)

424 ± 18

4.3

6.0

 

LC-HRMS

398 ± 16

0.7

9.7

100

LC-MS(SIM)

98 ± 8

8.5

-2.0

 

LC-HRMS

101 ± 5

0.4

4.1

50

LC-MS(SIM)

49 ± 5

10.2

-2.0

 

LC-HRMS

52 ± 5

7.7

8.7

Table 1: Accuracy and precision of the quantification of captopril in the DBS samples.
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