Captopril concentration in whole blood (ng/ml)

DBS volume
(ml)

Mean concentration found ±SD
(ng/ml) (n=6)

Precision
(% RSD)

Accuracy (%bias)

400

40

405 ± 59

14.7

1.3

 

30

424 ± 18

4.3

6.0

 

20

399 ± 23

5.9

-0.3

100

40

102 ± 9

9.2

2.0

 

30

98 ± 8

8.5

-2.0

 

20

94 ± 13

14.1

-6.0

50

40

48 ± 4

9.3

-4.0

 

30

49 ± 5

10.2

-2.0

 

20

48 ± 6

11.5

-4.0
Table 4: Accuracy and precision of the quantification of captopril in the DBS samples.
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