Route of administration

Oral

Formulation 1

Formulation 2

Intravenous

Dose (mg/kg)

50

50

10

AUC(0-t)(µg.hr/mL)

5.87 ± 0.24

11.61 ± 0.28

7.50 ± 0.94

Cmax/C0(µg/mL)

1.31 ± 0.06

1.0 ± 0.12

5.29 ± 1.41

Tmax(hr)

3.00

2.00

-

Kel  (1/hr)

-

-

0.62 ± 0.10

t1/2( hr)

-

-

1.14 ± 0.20

Vd(lit)

-

-

1.99 ± 0.49

Cl(ml/kg/min)

-

-

22.48 ± 0.16

bioavailability (%)

16.7

33.02

 
t is 5 and 24 h for iv and oral, respectively
Table 5: Pharmacokinetic parameters of BITS 17 following oral and intravenous administration.
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