Group Parameter Human subjects Group Parameter Experimental animals
Control Lead exposed Control Low dose exposure (2000 ppm) High dose exposure (4000 ppm)
MDA( nmol/dl) 18.73 ± 7.4 39.68a ± 2.84 MDA (nmol/g) 4.30 ± 2.18 9.52a ± 2.26 24.16a,b ± 4.13
GSH (mg/dl) 34.5 ± 7 12.6a ± 4.75 GSH (mg/g) 12.97 ± 0.87 24.57a ± 6.74 10.94b ± 2.77
SOD (U/dl) 5.46 ± 0.43 4.16 ± 0.22 SOD (U/g) 34.5 ± 1.6 28.5 ±1.6 21.4a,b ± 2.1
Results are presented as means ± SD (n=8 for each mice group and 15 for human group)
a=Significant difference (P<0.05) comparing to the normal control group (mice or human)
b=Significant difference (P<0.05) comparing to 2000 ppm lead acetate (low dose) group
Table 2: Oxidative stress biomarkers in human sera and mice brain of control and different lead exposed subject.
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