Group Parameter Human subjects Group Parameter Experimental animals
Control Lead exposed Control Low dose exposure (2000 ppm) High dose exposure (4000 ppm)
Serotonin (µg/dl) 0.92 ± 0.05 1.03 ± 0.07 Serotonin (µg/g) 0.83 ± 0.1 1.09a ± 0.08 1.24a,b ± 0.06
Dopamine (µg/dl) 0.47 ± 0.04 0.25 ± 0.03 Dopamine (µg/g) 1.45 ± 0.07 0.78a ± 0.04 0.64a,b ± 0.05
Results are presented as means ± SD (n=8 for each mice group and 15 for human group)
a=Significant difference (P<0.05) comparing to the normal control group (mice or human)
b=Significant difference (P<0.05) comparing to 2000 ppm lead acetate (low dose) group
Table 5: Monoamines content in mice brains (μg/g) and human serum (μg/dl) in control and different lead exposed animals and human subjects.
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