• E [β26(B8)Glu → Lys] • Volga [β27(B9)Ala → Asp] • Genova [β28(B10)Leu → Pro] • St. Louis [β28(B10)Leu → Gln] • Tacoma [β30(B12)Arg → Ser] • Abraham Lincoln [β32(B14)Leu → Pro] • Castilla [β32(B14)Leu → Arg] • Philly [β35(C1)Tyr → Phe] • Rush [β101(G3)Glu → Gln] • Peterborough [β111(G13)Val → Phe] • Madrid [β115(G17)Ala → Pro] • Khartoum [β124(H2)Pro → Arg] • J. Guantanamo [β128(H6)Ala → Asp] • Wien [β130(H8)Tyr → Asp] • Leslie [β131(H9)Gln → deleted] • Torino [α43(CD1)Phe → Val] • L. Ferrara [α47(CD5)Asp → Gly] • Setif [α94(G1)Asp → Tyr] • St. Lukes [α95(G2)Pro → Arg]

Table 3: Unstable hemoglobin variants, showing sites of amino acid substitutions (or deletions), redrawn from Sugawara et al. [34]. Each individual row illustrates variant´s name, the residue concerned (chain; number; position), and replacement (from → to), respectively.

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