| Flavonoid or Extract |
Origin |
Human cell Lines |
Biological Effects |
Reference |
| Flavonoid rich Extract |
Scutellaria baicalensis |
Glioma cell lines |
Growth inhibition and apoptosisss |
Scheck et al., [7] |
| Flavonoid rich extract |
Vaccinia macrocarpa |
U87 |
Growth inhibition |
Ferguson et al., [8] |
3,3',4',5,6-Pentahydroxyflavone
(quercetina; rutinaglycone) |
Many plants (i.e capparis spinosa, Anethum graveolens, Allium cepa) commercialized |
U138MG |
Growth inhibition |
Braganhol et al., [9] |
3',4',5,7-tetrahyidroxyflavone
(kaempferol) |
Many plants (i.e Allium, Delphinium,
Camellia) commercialized |
LN229, U87MG,
T98G,
GL-15 |
Apoptosis through oxidative stress |
Sharma et al., [10] |
| Silibinin |
Sylibummarianum |
U251MG |
Sensibilizated human glioma cells to
TRAIL-mediated apoptosis |
Son et al., [11] |
5-hydroxy-7,4-dimethoxyflavone,
casticin, apigenin, and penduletin |
Croton betulaster |
GL-15 |
Growth inhibition Down regulation of
TGF-β |
Freitas et al, [11] |
| Penduletin |
|
GL-15 |
Astroglial differentiation |
Santos et al., [14] |
| Rutin |
Dimorphandamollis |
GL-15 |
Growth inhibition and apoptosis,
Astroglial differentiation Down
regualation of TGF-β1 and VEGF |
Santos et al., [14]
Freitas et al, [11] |
| Hinokiflavone-8methyl-crisilliol |
|
U251MG; TG-1 |
Growth inhibition |
Costa et al., not published |
(*Human cell lines derived from primary and recurrent brain tumors) |
