Flavonoid or Extract Origin Human cell Lines Biological Effects Reference
Flavonoid rich Extract Scutellaria baicalensis Glioma cell lines Growth inhibition and apoptosisss Scheck et al., [7]
Flavonoid rich extract Vaccinia macrocarpa U87 Growth inhibition Ferguson et al., [8]
3,3',4',5,6-Pentahydroxyflavone
(quercetina; rutinaglycone)
Many plants (i.e capparis spinosa, Anethum graveolens, Allium cepa) commercialized U138MG Growth inhibition Braganhol et al., [9]
3',4',5,7-tetrahyidroxyflavone
(kaempferol)
Many plants (i.e Allium, Delphinium,
Camellia) commercialized
LN229, U87MG,
T98G,
GL-15
Apoptosis through oxidative stress Sharma et al., [10]
Silibinin Sylibummarianum U251MG Sensibilizated human glioma cells to
TRAIL-mediated apoptosis
Son et al., [11]
5-hydroxy-7,4-dimethoxyflavone,
casticin, apigenin, and penduletin
Croton betulaster GL-15 Growth inhibition Down regulation of
TGF-β
Freitas et al, [11]
Penduletin   GL-15 Astroglial differentiation Santos et al., [14]
Rutin Dimorphandamollis GL-15 Growth inhibition and apoptosis,
Astroglial differentiation Down
regualation of TGF-β1 and VEGF
Santos et al., [14]
Freitas et al, [11]
Hinokiflavone-8methyl-crisilliol   U251MG; TG-1 Growth inhibition Costa et al., not published
(*Human cell lines derived from primary and recurrent brain tumors)
Table 1: Effect of flavonoids obtained from different plants in glioma cells.
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