| Cell Line |
Cancer Cell Type |
S. spinescens extract |
| Aqueousa |
Methanola |
Ethanola |
Acetonea |
Acetone GI50b |
| HT29 |
Colon |
19 ± 3 |
52 ± 3 |
29 ± 2 |
80 ± 5 |
65 ± 5.8 |
| U87 |
Glioblastoma |
26 ± 13 |
34 ± 5 |
22 ± 3 |
41 ± 3 |
110 ± 13 |
| SJ-G2 |
Glioblastoma |
30 ± 4 |
52 ± 4 |
54 ± 7 |
83 ± 4 |
20 ± 9.5 |
| SMA |
Glioblastoma (Murine) |
25 ± 6 |
42 ± 3 |
33 ± 0.2 |
80 ± 1 |
49 ± 3.5 |
| MCF-7 |
Breast |
44 ± 8 |
68 ± 4 |
65 ± 1 |
82 ± 3 |
12 ± 6.5 |
| MCF10A |
Breast (Normal)c |
18 ± 5 |
42 ± 9 |
20 ± 4 |
66 ± 7 |
67 ± 17 |
| A2780 |
Ovarian |
33 ± 6 |
66 ± 4 |
47 ± 7 |
89 ± 1 |
28 ± 2.6 |
| H460 |
Lung |
29 ± 4 |
55 ± 2 |
34 ± 4 |
57 ± 3 |
81 ± 4.1 |
| A431 |
Skin |
36 ± 1 |
57 ± 2 |
27 ± 2 |
85 ± 3 |
50 ± 4.2 |
| Du145 |
Prostate |
43 ± 4 |
66 ± 3 |
41 ± 4 |
83 ± 3 |
36 ± 13 |
| BE2-C |
Neuroblastoma |
39 ± 0.5 |
54 ± 4 |
32 ± 5 |
53 ± 4 |
91 ± 12 |
| MiaPaCa2 |
Pancreas |
24 ± 5 |
50 ± 4 |
28 ± 1 |
70 ± 3 |
66 ± 5.2 |
|
aPercentage growth inhibition in response to 100 μg/mL of extract, the higher the value the greater the inhibition.
bConcentration (μg/mL) that inhibits cell growth by 50%; the lower the value the greater the inhibition.
cBreast cell line derived from normal non-tumour derived tissue |
| Table 4: Cell growth inhibition of S. spinescens extract across various cell lines. |
