Cell Line Cancer Cell Type S. spinescens extract
Aqueousa Methanola Ethanola Acetonea Acetone GI50b
HT29 Colon 19 ± 3 52 ± 3 29 ± 2 80 ± 5 65 ± 5.8
U87 Glioblastoma 26 ± 13 34 ± 5 22 ± 3 41 ± 3 110 ± 13
SJ-G2 Glioblastoma 30 ± 4 52 ± 4 54 ± 7 83 ± 4 20 ± 9.5
SMA Glioblastoma (Murine) 25 ± 6 42 ± 3 33 ± 0.2 80 ± 1 49 ± 3.5
MCF-7 Breast 44 ± 8 68 ± 4 65 ± 1 82 ± 3 12 ± 6.5
MCF10A Breast (Normal)c 18 ± 5 42 ± 9 20 ± 4 66 ± 7 67 ± 17
A2780 Ovarian 33 ± 6 66 ± 4 47 ± 7 89 ± 1 28 ± 2.6
H460 Lung 29 ± 4 55 ± 2 34 ± 4 57 ± 3 81 ± 4.1
A431 Skin 36 ± 1 57 ± 2 27 ± 2 85 ± 3 50 ± 4.2
Du145 Prostate 43 ± 4 66 ± 3 41 ± 4 83 ± 3 36 ± 13
BE2-C Neuroblastoma 39 ± 0.5 54 ± 4 32 ± 5 53 ± 4 91 ± 12
MiaPaCa2 Pancreas 24 ± 5 50 ± 4 28 ± 1 70 ± 3 66 ± 5.2
aPercentage growth inhibition in response to 100 μg/mL of extract, the higher the value the greater the inhibition.
bConcentration (μg/mL) that inhibits cell growth by 50%; the lower the value the greater the inhibition.
cBreast cell line derived from normal non-tumour derived tissue
Table 4: Cell growth inhibition of S. spinescens extract across various cell lines.
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