Parameters Normal control Diabetic control  SAE treated (100mg/ kg BW) SAE treated (200mg/ kg BW) Glibenclamide treated (600μg/kg) GSH (mM of DTNB conjugated/ mg protein) Liver Kidney 129.67 ± 2.66 118.77 ± 2.31 74.23 ± 1.51z 46.17 ± 2.49z 82.46 ± 2.27a 62.15± 3.56 98.12 ± 3.34c 69.38 ± 2.78 130.56 ± 1.41c 95.17 ± 2.55 (NS) GST (m mol of CDNB-GSH conjugate formed/ min/ mg protein) Liver Kidney 6.75 ± 0.97 6.88 ± 0.34 3.42 ± 0.18 z 2.66 ± 0.27 3.56 ± 0.83b 3.09 ± 0.54a 3.98 ± 0.28c 3.68 ± 0.38b 5.12 ± 0.11b 3.76 ± 0.91b GPx (mg glutathione consumed/ min/ mg protein) Liver Kidney 9.38 ± 0.91 7.33 ± 0.14 5.19 ± 0.88 z 4.99 ± 1.01y 5.82 ± 0.76b 5.08 ± 0.14a 6.42 ± 0.54c 5.92 ± 0.26c 7.24 ± 0.61b 5.66 ± 0.58a CAT (mmol of H2O2 consumed/ min/ mg protein) Liver Kidney 71.25 ± 2.17 38.33 ± 1.22 38.67 ± 1.92 z 20.55 ± 1.75 z 44.32 ± 2.59b 21.26 ± 1.08a 58.45 ± 1.26c 28.52 ± 1.41c 65.31 ± 2.56c 35.24 ± 1.81c SOD (U/ min/ mg/ Hb) Erythrocytes 6.34 ± 0.19 3.41 ± 0.22 z 5.97 ± 0.62b 5.32 ± 0.43c 4.28 ± 0.24b

The values represent the means ± S. D. for six rats per group. ap<0.05, bp<0.01 and cp<0.001 compared to diabetic control group.yp<0.01, zp<0.001 as compared to normal; SOD: superoxide dismutase; GSH: Glutathione; GPx: glutathione peroxidase; GST: glutathione-S-transferase; CAT: Catalase.

Table 1: Effect of S. asoca extract on antioxidant enzyme activities in STZ-nicotinamide diabetic rats.

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