PK Parameter Piperacillin (Mean ± SD ) Ceftazidime (Mean ± SD )
This study Occhipinti et al. [15] This study Lüthy et al. [16]
t1/2 (h) 3.1 ± 1.3 0.8 ± 0.1 17.6 ± 16.6 1.9 ± 0.2
Vd (L) 22.2 ± 11.2 10.5 ± 1.4 13.5 ± 5.6 14.7 ± 1.4
CL (mL・min-1) 95.2 ± 15.1 182.0 ± 20.0 24.7 ± 34.5 116.0 ± 18.0

SD, standard deviation; t1/2, elimination half-time;
Vd, volume of distribution; CL, total drug clearance
Table 2: Comparison of piperacillin and ceftazidime pharmacokinetic parameters in this study versus published data for healthy volunteers.
Goto home»