Parameters Control 200 µg/ml 400 µg/ml 800 µg/ml
Creatinine (mg/dl) 0.40 ± 0.01 0.44 ± 0.05 0.44 ± 0.03 0.48 ± 0.02*
BUN (mg/dl) 13.44 ± 2.53 14.52 ± 1.87 14.81 ± 1.66 14.91 ± 1.66
AST (IU/l) 63.40 ± 1.03 64.80 ± 1.46 64.20 ± 2.20 66.80 ± 1.11
ALT (IU/l) 13.97 ± 2.14 15.11 ± 1.75 15.71 ± 3.27 17.46 ± 2.76
γ-GT (IU/l) 1.48 ± 0.26 1.70 ± 0.26 1.70 ± 0.26 1.91 ± 0.21
ALP (IU/l) 30.40 ± 2.76 33.17 ± 3.39 35.93 ± 3.39 35.93 ± 3.39
Bilirubin (mg/dl) 0.32 ± 0.01 0.35 ± 0.01 0.35 ± 0.02 0.38 ± 0.01*
PT (s) 6.20 ± 0.37 6.80 ± 0.37 6.80 ± 0.37 6.60 ± 0.51

BUN blood urea nitrogen; AST aspartate aminotransferase; ALT alanine aminotransferase; γ-GT gamma glutamyl transpeptidase; ALP alkaline phosphatase; PT prothrombin time.
N=5 animals per group. The values are mean ± standard error of mean.
* Means statistically different from the control group at p<0.05.
Table 1: Serum biochemical profile of Wistar male rats treated with different concentrations of crude Quassia amara extract through drinking water after 90 days of exposure.
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