Parameters Control 200 µg/ml 400 µg/ml 800 µg/ml
Creatinine (mg/dl) 0.41 ± 0.01 0.40 ± 0.01 0.42 ± 0.01 0.43 ± 0.02
BUN (mg/dl) 12.52 ± 1.47 15.82 ± 1.35 15.82 ± 1.35 15.94 ± 1.47
AST (IU/l) 68.00 ± 1.23 72.00 ±1,23 74.00 ± 2.74 78.00 ± 3.0*
ALT (IU/l) 13.97 ± 2.14 21.46 ± 4.28 24.44 ± 4.28* 29.68 ± 2.14*
γ-GT (IU/l) 1.29 ± 2.14 1.52 ± 0.28 1.52 ± 0.28 1.98 ± 0.23
ALP (IU/l) 30.40 ± 5.17 30.40 ± 5.17 33.17 ± 3.38 38.70 ± 2.76*
Bilirubin (mg/dl) 0.36 ± 0.001 0.37 ± 0.01 0.37 ± 0.01 0.37 ± 0.01
PT (s) 6.80 ± 0.20 6.80 ± 0.37 7.20 ± 0.37 7.40 ± 0.51

BUN blood urea nitrogen; AST aspartate aminotransferase; ALT alanine aminotransferase; γ-GT gamma glutamyl transpeptidase; ALP alkaline phosphatase; PT prothrombin time.
N=5 animals per group. The values are mean ± standard error of mean.
*Means statistically different from the control group at p<0.05.
Table 3: Serum biochemical profile of Wistar female rats treated with different concentrations of crude extract of Quassia amara through drinking water after 90 days of exposure.
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