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| Figure 2: A subset of IEGs likely act downstream of viral subversion of IFN.IFN signaling events lead to upregulation of IFN stimulated genes (ISGs) via an IFN stimulated response element (ISRE). Viruses subvert early IFN signaling events through multiple mechanisms. For example, HCV core and NS5A proteins, and a conserved function of DENV, WNV, and YFV NS4B protein, all inhibit STAT1 activation by IFN (red box). We hypothesize that several IFN effectors activate downstream antiviral events that may circumvent this inhibition. |
