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| Figure 1: Schematic representation of the isolation of the GLC14/16/19 series of SCLC cell lines and CSC marker expression. GLC14 cell line was established from the first biopsy upon diagnosis, GLC16 line following radiochemotherapy (CDE – cyclophosphamide/doxorubicin/ etoposide chemotherapy; X – radiation therapy; CR – complete response; PR – partial response) and GLC19 line after local radiation therapy and before progression and termination of therapy. Stem cell markers exhibiting increased expression at the transcript level relatively to GLC14 cells are shown at the right side of the figure for GLC16 and GLC19 cells, respectively. |
