Author Year Country Ethnicity Mean or median age of cases/controls or age range (years) Source of control Matching criteria Case/control Genotyping methods Studied polymorphism (Fok1 or/and Bsm1) HWE
Curran 1999 Australia Caucasian 59.6 ± 1.01/49.7 ± 1.35 Population Age 135/110 PCR-RFLP Fok1 Y
 Ingles 2000 American Caucasian 45-75/45-75 Hospital Age ,Residential area 143/300 PCR-RFLP Bsm1 Y
 Hou 2002 Chinese Asian 49.03 ± 11.67/33.07 ± 12.3&59.79 ± 9.68 Population Residential area 34/215 PCR-RFLP Bsm1 Y
Buyru 2003 Turkey Caucasian NR /NR Population NA 78/27 PCR-RFLP Bsm1 Y
 Guy 2004 UK Caucasian 60.5(27-90)/54(36-80) Hospital Age 398/427 PCR-RFLP Fok1,Bsm1 Y;Y
 Chen 2005 Turkey Caucasian 57.1(43-69)/57.9(43-69) Hospital Age and Residential area 2,414/3,223 TaqMan Fok1,Bsm1 Y;Y
 Lowe 2005 UK Caucasian 58(34-84)/58(36-80) Hospital Age ,Residential area 179/179 PCR-RFLP Bsm1 Y
McCullough 2007 America Caucasian 62(43-75)/ 62(43-75) Hospital Age ,Race ,Residential area 500/500 TaqMan Fok1,Bsm1 Y
John 2007 American Hispanics, African Americans, non-Hispanic White                                                35-79/35-79 Population Age, Regional match 764/865 TaqMan Fokl Y
 Sinotte1 2008 Canada Caucasian 52.3 ± 9.7/52.3 ± 9.7 Hospital and Population Age,Region 243/423 Allele-specific PCR Fok1,Bsm1 Y;N
 Sinotte2 2008 Canada Caucasian 55.8 ± 10.5/55.8 ± 10.5 Population Age,Region 622/974 Allele-specific PCR Fok1,Bsm1 Y;Y
Abbas 2008 Germany Caucasian 50-74/NR Population Age 1,390/2,596 PCR-RFLP Fok1 Y
Gapska 2008 Polish Caucasian 56.5(25-88)/56.5(25-88);44.2(21-50)/45.3(22-50) Population Age, Region 1,760/1,510 TaqMan(R) Fok1,Bsm1 Y;Y
 McKay1 2009 American mixed 70 ± 6/58 ± 8 Population Age, Hormone status 6473/8397 Taqman Fok1,Bsm1 Y;Y
 McKay2 2009 American Caucasian 70 ± 6/58 ± 8 Population Age, Hormone status 1,605/2,136 Taqman Fok1,Bsm1 Y;N
 Rollison 2011 American Caucasian 24-79/24-79 Population Age, regional area 2318/2521 PCR-RFLP Fok1,Bsm1 Y;Y
Anderson 2011 Canada Caucasian 56/56 Population Age 1560/1633 MassARRAY system Fokl,Bsm1 N;Y
Engel 2012 American Caucasian 58.3 ± 10.0/62.8 ± 8.9 Population Race ,Regional area, Age 269/552 MassARRAY system Fokl Y
Fuhrman 2013 American Caucasian 43.4 ± 10.0/45.2 ± 10.6 Population Age, Region, Year of birth ,in 5-year intends 484/845 TaqMan orMGB Edipse assays Fok1,Bsm1 Y;Y
Shahbazi 2013 Iranian Asian 45.44 ± 10.61/42.64 ± 9.67 Population Age 140/156 PCR-RFLP Fok1,Bsm1 Y;Y
NR: not reported; Sinotte1: one study by Sinotte et al.; Sinotte2 :another study by Sinotte et al.; Mckay1:the study in mixed ethnicity by Mckay et al.; Mckay2:the study only in Caucasian by Mckay et al.
Table 1: The main characteristics of all the studies in this meta-analysis.
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