| Platform Used |
Stem Cell Studied |
Key Findings |
Reference |
| Microtiter |
hPSC |
Small molecule (Y-27632) promotes hPSC single cell survival |
[31] |
| DE |
Developed 5 compound cocktail that promotes hPSC survival |
[32] |
| PP |
Identified four compounds to promote hPSC self-renewal |
[33] |
| CM |
EHNA maintains long-term hPSC pluripotency |
[34] |
| NESCs |
PEDF, signaling through the Erk1/2 signaling pathway, sustains long-term maintenance of hPSCs |
[35] |
| Combinatorial Protein Array |
hPSCs |
Defined ECMP for growth of hPSCs |
[45] |
| MPCs |
Laminin-1 maintained MPCs in a quiescent state while P-cadherin directed differentiation into a myoepithelial cell type |
[44] |
| NPCs |
Wnt and Notch co-stimulation maintain NPCs in a multipotent state whereas BMP-4 induces differentiation into neuronal and glial fates |
[43] |
| Biomaterial Array |
hPSCs |
Substrates supported optimal hPSC growth have moderate wettability and relied on integrin aVB3 and avB5 engagement with adsorbed Vn to promote hPSC expansion |
[53] |
| hPSCs |
Heparin mimicking polymer supports long-term hPSC growth of multiple hPSC lines |
[54] |
| ECs |
Differentiation of hPSCs into ECs |
[50] |
| HE |
Novel substrates for the generation of HE from hPSCs |
[55] |
| MSCs |
Phosphate surfaces promote osteoblast formation while t-butyl-modified surfaces direct adipocyte formation |
[51] |
| Microwell Array |
hPSCs |
Small EBs form neuroectoderm whereas large EBs tend towards a mesoendoderm fate |
[63] |
| |
EB size regulates the amount of endothelial and cardiac differentiation in hPSCs through differential Wnt signaling |
[64] |
| HSCs |
Proliferation and differentiation of HSCs decreases in microwells of smaller size |
[58] |
| NPCs |
Viability of neurospheres enhanced by controlling their size |
[60] |
| Microfluidic |
hPMPCs |
Combination of shear stress and VEGF increases endothelial differentiation of hPMPCs |
[66] |
| NPCs |
Differentiation of NPCs directly proportion to Shh concentrations in the gradient |
[68] |
