Parameters

Test

Reference

P valueψ

90 %CIφ
(80-125 %)

T/R ratio

Cmax (µg/ml)

19.527±0.809

19.291±0.855

0.35

99.65-101.23

101.3088

Tmax (h)

1.08±0.056

1.17±0.077

0.31

 

 

Kele (l/hr)

0.371±0.063

0.352±0.052

0.93

T1/2 (h)

2.994±0.478

2.520±0.414

0.34

AUC0-t (µg.h/ml)

90.024±2.645

90.818±3.173

0.89

100.31-104.24

99.30043

AUC0-inf  (µg.h/ml)

94.671±3.904

98.117±5.573

0.69

100.25-105.94

97.16596

Table 4a: Pharmacokinetic Parameters after Single Oral Dose of 600 mg Amtolmetin Guacil Tablet in 12 Healthy Male Volunteers. Pharmacokinetic Parameters of Tolmetin.
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