Drug

Parameter

Partial AUC0- 72

Partial AUC0-2 X t/2

Baseline value (total AUC)

Bicalutamide
N = 39

CI_90_Lower

85.89

83.53

86.00

CI_90_Upper

99.57

95.63

96.13

Ratio[%Ref]

92.48

89.37

91.08

Topiramate
N=26

CI_90_Lower

99.1

98.45

98.23

CI_90_Upper

103.86

103.42

102.68

Ratio[%Ref]

101.45

100.9

100.43

Amitryptiline
N=24

CI_90_Lower

95.14

*

95.79

CI_90_Upper

109.59

110.45

Ratio[%Ref]

102.11

102.86

* Not applicable as T1/2 hrs х 2 is less than 72 hrs

Table 2: Study results after AUC truncation at different time points

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