Drug
Parameter
Partial AUC0- 72
Partial AUC0- 2 X t/2
Baseline value (total AUC)
Bicalutamide
Intra-subject variability
19.50
17.84
17.39
Percent change from baseline
12.13
02.58
NA
Topiramate
04.94
05.17
04.66
06.00
10.94
Amitryptiline
14.33
**
14.43
0.69
** Not applicable as T1/2 hrs. X 2 is less than 72 hrs
Table 3: Intra-subject variability for AUC with percent change from baseline obtained after truncation of AUC at different time points.