Drug

Parameter

Partial AUC0- 72

Partial AUC0- 2 X t/2

Baseline value (total AUC)

Bicalutamide

Intra-subject variability

19.50

17.84

17.39

Percent change from baseline

12.13

02.58

NA

Topiramate

Intra-subject variability

04.94

05.17

04.66

Percent change from baseline

06.00

10.94

NA

Amitryptiline

Intra-subject variability

14.33

**

14.43

Percent change from baseline

0.69

NA

** Not applicable as T1/2 hrs. X 2 is less than 72 hrs

Table 3: Intra-subject variability for AUC with percent change from baseline obtained after truncation of AUC at different time points.

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