Parameter

Test*

Reference†

Cmax, ng/ml

3610 (1344)

3448 (1214)

Adjusted Cmax, kg ·ng/ml/mg

5444 (1711)

5269 (1678)

AUC0–t, ng·h /ml

5720 (2527)

5521 (2454)

Adjusted AUC0–t, kg · ng·h /ml/mg

8738 (3643)

8515 (3675)

AUC0–∞, ng·h/ml.

6292 (2548)

6097 (2415)

Adjusted AUC0–∞, kg · ng·h /ml/mg

9625 (3681)

9399 (3694)

Tmax, h

2.56 (0.99)

3.12 (1.48)

t1/2, h

0.98 (0.29)

0.96 (0.33)


AUC0–t =AUC from time 0 (baseline) to the last measurable concentration
AUC0–∞= AUC from baseline extrapolated to infinity
*Trademark: Prazolan® (Laboratorios Liomont, S. A. de C. V., Mexico City, Mexico)
†Trademark: Pantozol® (NYCOMED, S. A. de C. V., Mexico City, Mexico)
Table 1: Pharmacokinetic parameters of a test and a reference formulation of oral pantoprazole 40 mg after a single administration in healthy Mexican adult subjects (n = 34). Values are mean (SD).
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