Parameter |
Olanzapine |
Test |
Reference |
% Geometric mean ratio,Test/Reference (90% CI) |
Power |
Cmax (ng/mL) |
27.6 (8.45) |
26.4 (8.45) |
95.76 (88.55-103.55) |
0.9978 |
AUC0-120 h (ng.h/mL) |
835 (355) |
805 (313) |
103.77 (97.49-110.46) |
0.9999 |
AUC0-∞ (ng.h/mL) |
901 (408) |
863 (366) |
104.39 (98.20-110.98) |
0.9999 |
Tmax (h) |
3.53 (1.00-6.00) |
3.00 (1.00-4.50) |
|
|
T1/2 (h) |
31.6 (5.18) |
30.4 (5.32) |
|
|
λz (h-1) |
0.0222 |
0.023 |
|
|
AUC = area under plasma concentration-time curve, Cmax = maximal plasma
concentration, Tmax = time for the maximal plasma concentration, T1/2 = half-life,
λz = elimination rate constant. Data shown as geometric mean (SD) and median
(range) for Tmax |
